Carbamates and their use as pharmaceuticals

Les carbamates et leur utilisation comme composes pharmaceutiques

Abstract

ABSTRACT OF THE DISCLOSURE: This invention is concerned with a process for the production of a new carbamate of the formula I: I, in which the dotted line denotes a double bond which may be hydrogenated, X is an alkylene bridge of 1 or 2 carbon atoms, R1 is hydrogen or alkyl of 1 to 4 carbon atoms, R2 is hydrogen, R3 is hydrogen and R4 is hydrogen, a linear of branched alkyl of 1 to 4 carbon atoms or a phenyl. This process comprises the steps of reacting a diene of the formula V: V, with a dienophile of the formula VI: VI, according to the Diels Alder reaction, at a temperature of from 15° to 220°C, and hydrogenating the double bond of the obtained unsaturated carbamate when desired. The so prepared new carbamate may be used as pharmaceuticals by virtue of their analgesic properties.

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